Si Belle BTX (2.5mL x 1ea)
Si Belle BTX — Botulinum-inspired Peptide Skin Booster
A peptide-based skin-booster concept designed for expression-related wrinkle care. The formulation combines five peptides associated with neurotransmitter signalling and muscle-contraction pathways, with a focus on visible smoothing of expression lines and relaxed-looking skin.
Product specifications
Product concept: Botulinum-inspired peptide skin booster
Presentation: 2.5 mL × 1 EA
Primary focus: Expression-related wrinkle care
Number of featured peptides: 5
Catalogue positioning: Botulinum toxin-free
Audience: Clinicians and professional distribution partners
From hydration to expression-line care
Conventional skin boosters focus on hydration and skin conditioning. Si Belle BTX introduces a peptide-based concept focused on expression-related wrinkles and the biological pathways associated with contraction signals.
The formulation concept combines botulinum-inspired peptide mechanisms with a skin-booster format. The product packaging carries the line “Less Resistance, More Resilience.”
Composition and primary functions
All five featured peptide ingredients are presented for anti-wrinkle application.
sr-(Oligopeptide-91 Clostridium Botulinum Polypeptide-1): Function in the catalogue: SNAP-25 mimic; Application: Anti-wrinkle
Arginine/Lysine Polypeptide: Function in the catalogue: Antagonist of ACh; Application: Anti-wrinkle
Acetyl Hexapeptide-8: Function in the catalogue: SNAP-25 mimic; Application: Anti-wrinkle
Acetyl Octapeptide-3: Function in the catalogue: SNAP-25 mimic; Application: Anti-wrinkle
Pentapeptide-18: Function in the catalogue: Enkephalin mimic; Application: Anti-wrinkle
How the peptide pathways are described
Acetylcholine release depends on the SNARE complex. The catalogue explains several peptide mechanisms at different points along the neurotransmission and muscle-contraction pathway.
sr-(Oligopeptide-91 Clostridium Botulinum Polypeptide-1): SNAP-25 cleavage; delivery-peptide and light-chain concept.
Arginine/Lysine Polypeptide: Nav1.4 sodium-channel blockade.
Acetyl Hexapeptide-8: Competitive inhibition associated with SNAP-25 and SNARE-complex formation.
Acetyl Octapeptide-3: Competitive inhibition associated with SNAP-25 and SNARE-complex formation.
Pentapeptide-18: Enkephalin-receptor binding, reduced calcium-channel opening and reduced acetylcholine release.
Recombinant peptide technology
The catalogue describes sr-(Oligopeptide-91 Clostridium Botulinum Polypeptide-1) as a recombinant, highly purified protein comprising the light chain of botulinum toxin. SNAP-25 is identified as the shared biological target, with direct enzymatic cleavage of the SNARE protein complex.
The source diagram compares a conventional heavy-chain + light-chain structure with a delivery-peptide + light-chain structure. Oligopeptide-91 is described as the delivery tag in the peptide concept.
Arginine/Lysine Polypeptide
A biomimetic peptide inspired by compounds found in cone-snail venom. The proposed activity concerns sodium channels on the surface of muscle fibres.
Following acetylcholine release and receptor binding, rapid sodium-ion influx is involved in the electrical signal that supports muscle contraction. The catalogue schematic places the peptide interaction at the sodium-channel stage.
Acetyl Hexapeptide-8 and Acetyl Octapeptide-3
These SNAP-25-derived peptides compete in SNARE-complex formation and reduce acetylcholine release. Acetyl Octapeptide-3 is described as a Hexapeptide-8 derivative with higher biological activity in the cited material.
Pentapeptide-18
Pentapeptide-18 is described through enkephalin-receptor binding and reduced calcium-channel opening, followed by reduced acetylcholine release.
The catalogue includes third-party images comparing Pentapeptide-18, Acetyl Hexapeptide-8 and their combination over 28 days.
Peptide concept compared with other formats
Feature: Botulinum toxin: Neurotoxin; Conventional skin booster: Hydration-focused; Si Belle BTX peptide concept: Peptide neuromodulation
Expected focus: Botulinum toxin: Muscle paralysis; Conventional skin booster: Skin conditioning; Si Belle BTX peptide concept: Wrinkle-relaxing concept
Source category: Botulinum toxin: Drug; Conventional skin booster: Cosmetic; Si Belle BTX peptide concept: Cosmetic-grade peptides
Analytical and cellular assays included in the brochure
The brochure presents SDS-PAGE qualitative / quantitative analysis and cellular viability assays in human epidermal cells and human dermal fibroblasts.
No cytotoxicity was observed at ingredient concentrations of 10 ppm or below compared with control in the reported assays.
Four-week human evaluation reported in the brochure
The catalogue reports a nasolabial-fold evaluation conducted by H&Bio Co., Ltd. / Korea Skin Clinical Research Center, with 21 subjects and a 1 ppm study formulation over four weeks.
The mean age was 49.43 ± 4.43 years, with a range of 41–54 years. The brochure reports wrinkle improvement and no adverse skin reactions during the study period.
Average depth of wrinkles: 2.65%
Mean depth of the biggest wrinkle: 5.22%
Maximum depth of the biggest wrinkle: 7.83%
Total wrinkle count: 19.54%
Total wrinkle volume: 6.93%
Total wrinkle area: 5.39%
Product format
Si Belle BTX is supplied in a burgundy-red carton as 2.5 mL × 1 EA. The formulation is presented as a botulinum-inspired peptide skin booster for clinicians and professional distribution partners, with expression-line care as its central product focus.
View the full Si Belle BTX product guide
){kind=link}